When Was Delta-8 Discovered? A Complete Cannabinoid Timeline

by Kat Austin March 22, 2021 5 min read

When Was Delta-8 Discovered? A Complete Cannabinoid Timeline - VO Inc

Delta-8-THC might seem like a recent addition to the world of cannabinoids, but its origins date back several decades. So, when was Delta-8 discovered? Delta-8-THC was first identified in the 1940s by pioneering cannabinoid researcher Roger Adams. Despite its long history, it has only recently gained prominence in the hemp industry.

Here’s a closer look at Delta-8's history and why it has only recently become popular.

Table of Contents
The Discovery of Delta-8-THC
Cannabis Research Limitations
When Was Delta-8-THC Discovered in Hemp?
Where to Buy Delta-8-THC Today
Resources

Looking for high-quality Delta-8-THC that ships to your door? We recommend checking out our Elev8 Collection.

Key Takeaways

  • Delta-8-THC was discovered in the 1940’s, but full synthesis wasn’t completed until the 1960’s.
  • Delta-8-THC research was halted in the U.S. in 1970 due to cannabis prohibition, but research continued in other parts of the world.
  • In the early 2000’s, an infamous cannabinoid researcher found that CBD (derived from legal hemp) could be converted into Delta-8-THC.

Delta 8 Discovery: How Long Has Delta-8 Been Around?

Delta-8-THC history can be dated back to 1941 when Roger Adams, an American organic Chemist, was the first to publish an article regarding the partial synthesis of Delta-8-THC. Shortly after, he and his colleagues at the University of Illinois began researching the psychoactive properties of Delta-8 and Delta-9.

A close up of hemp material grown for research purposes, like discovering Delta-8's therapeutic properties.

Total synthesis of the Delta-8-THC was reportedly achieved in 1965 by Raphael Mechoulam, an Israeli organic chemist who is often referred to as “the father of cannabis.” The article depicting the full pharmacology of Delta-8 and other cannabinoids wasn’t published until 1970, however.

At the time of discovery, Delta-8-THC was frequently referred to as Delta-6-THC (Δ6-THC), but has been more accurately renamed Delta-8-THC as we’ve learned more about the whole molecule and its double bond placement (which is at carbon chain position 8).

Cannabis Research Limitations

Although Delta-8-THC was discovered in the early 1940’s, most Delta-8 research was halted in the United States when cannabis was ruled illegal under the Controlled Substances Act in 1970.

After this law was passed, Cannabis research required a special government permit that wasn’t frequently granted. When it was, it was commonly used to research the more abundant psychoactive cannabinoid, Delta-9-THC.

Under the Controlled Substances Act, Delta-8-THC was deemed illegal under U.S. federal law, and Delta-8 products could only be found in certain state-licensed dispensaries in areas where cannabis is legal.

Delta-8-THC accessibility changed, however, when it was recognized as a hemp-derivative and hemp was officially legalized under the 2018 Farm Bill.

When Was Delta-8-THC Discovered in Legal Hemp?

It’s important to note that Raphael Mechoulam carried out his research in Israel and was not subject to the same laws as U.S. researchers. He and his colleagues continued research on Delta-8-THC (and many other cannabinoids) for decades.

An inside look at a hemp extraction lab where the CBD to Delta-8-THC conversion process takes place.

His work on Delta-8 was frequently scrutinized, however, since it was only available in trace amounts in many cannabis strains, and was therefore difficult to source in the amounts needed for therapeutic doses.

Mechoulam’s work on Delta-8 began to make more sense when he filed for a patent in the early 2000’s regarding a process called “isomerization” which successfully converts CBD to Delta-8-THC. (Read “Here’s How Delta-8-THC is Made” to learn more about the isomerization process.)

CBD, the most abundant cannabinoid found in legal hemp, is now much more accessible even in the U.S. where cannabis is federally prohibited. A variety of different isomerization methods are used today to convert high-quality CBD to Delta-8-THC, which makes legal Delta-8 accessible in many states across the U.S.

Timeline of Delta-8 History (+ Other Cannabinoids)

The journey of understanding cannabinoids extends far beyond just Delta-8 and Delta-9 THC. Here’s a concise timeline of key discoveries in the history of cannabinoids:

1940s

  • Early Discoveries: In the 1940s, chemist Roger Adams and his team at the University of Illinois made the initial extraction of cannabinoids, including THC and CBD. However, they did not isolate pure Delta-8 or Delta-9 THC, but rather a mix of cannabinoids.

1960s

  • Breakthrough Research: The 1960s saw a surge in cannabinoid research, driven by the growing popularity of cannabis. Researchers identified Delta-9 THC and distinguished it from non-psychoactive cannabinoids like CBD and CBN. This era focused on understanding the psychoactive effects of THC.

1970s

  • Metabolic Studies: Research in the 1970s concentrated on the pharmacokinetics of Delta-9 THC, exploring how it metabolized in the body. The endocannabinoid system was not yet discovered, which complicated these studies.

1980s

  • Receptor Discovery: The mid-1980s brought significant advancements with the identification of cannabinoid receptors in the body by Allyn Howlett’s lab. This discovery laid the groundwork for understanding the endocannabinoid system.

2000s – Today

  • Modern Advances: The past two decades have seen an explosion of research into cannabinoids, including the recent discovery of THC-P in 2019. THC-P, discovered by Italian researchers using advanced mass-spectrometry, is reported to be significantly more potent than Delta-9 THC.

As research continues, the cannabis field will likely unveil even more cannabinoids and their effects. Stay tuned for ongoing updates in cannabinoid science.

Where to Buy Delta-8-THC Today

Don’t let Delta-8’s popularity fool you—it isn’t a new, unsubstantiated trend. Delta-8 has been around for decades, and prominent cannabinoid researchers have been evaluating it’s medicinal potential for years.

Luckily, Delta-8-THC is now legal in most U.S. states, and can be ordered online and shipped directly to your door. Our entire selection of Delta-8-THC products is 100% Farm Bill compliant and made according to stringent legal and quality standards, and ships to all areas where Delta-8 is legal in the U.S.

Vida Optima Elev8 Tincture

FAQ - When Was Delta 8 Disovered?

Is Delta-8 natural or synthetic?

Delta-8 THC is a naturally occurring cannabinoid found in small amounts in cannabis and hemp plants. However, the majority of Delta-8 products are synthesized from CBD through a chemical process, as natural Delta-8 is found in too low of concentrations for mass production.

Is Delta-8 psychoactive?

Yes, Delta-8 is psychoactive, but its effects are milder compared to Delta-9 THC. Users report a smoother, more relaxing high with less anxiety or paranoia than what’s commonly associated with Delta-9.

Is Delta-9 stronger than Delta-8?

Yes, Delta-9 THC is stronger than Delta-8 THC. Delta-9 is more potent and produces more intense psychoactive effects, while Delta-8 is known for providing a lighter, more clear-headed experience.

Does Delta-8 show up on drug tests?

Yes, Delta-8 can show up on drug tests. Standard drug tests typically screen for THC metabolites, and since Delta-8 metabolizes similarly to Delta-9, it can trigger a positive result.

Is Delta-8 legal in all 50 states?

No, Delta-8 is not legal in all 50 states. While it's federally legal due to the 2018 Farm Bill, several states have enacted laws banning or restricting Delta-8 THC, so it's important to check your local regulations.

Does Delta-8 have long-term effects?

Research on the long-term effects of Delta-8 is limited. Like other cannabinoids, prolonged use could potentially lead to tolerance, dependence, or cognitive effects, but more studies are needed to fully understand its long-term impact.

Resources

  1. “Structure of Cannabidiol. XII. Isomerization to Tetrahydrocannabinols” https://pubs.acs.org/doi/abs/10.1021/ja01853a052
  2. “Marihuana: Harvey Lecture, February 19, 1942” https://pubmed.ncbi.nlm.nih.gov/19312292/
  3. “Marihuana Chemistry” https://science.sciencemag.org/content/168/3936/1159
  4. “Cannabinoid pharmacology: the first 66 years” https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1038/sj.bjp.0706406
  5. “The Federal Controlled Substances Act: Schedules and Pharmacy Registration” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839489/#:~:text=The%20Federal%20Comprehensive%20Drug%20Abuse,effective%20on%20May%201%2C%201971.&text=The%20goal%20of%20the%20Controlled,and%20dispensing%20of%20controlled%20substances.
  6. “Conversion of CBD to Δ8-THC and Δ9-THC” https://patents.google.com/patent/US7399872B2/en

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